The increasing advancement in Internet of Things (IoT) and Industry 4.0 inspires more connectivity of vital infrastructure to the cloud. Securing our infrastructure digital and control systems is currently a crucial demand in a cyber-world characterized by continuous cybersecurity attacks. Preparing qualified students to satisfy the current and future work force requirement in cybersecurity is deemed essential. One of the main cybersecurity domain challenges is its interdisciplinary nature that involves scientists, engineers, technologists, and business teams. It is almost impossible in real life to mitigate threats and defend against attacks without assembling teams and qualified team members with skills in all the aforementioned disciplines. This paper aims at presenting the plan and procedures required for creating an project based interdisciplinary course at cybersecurity of frontier technologies between the College of Engineering, College of Science, and College of Business Administration. The course objective is to bring students from the three disciplines into a multidisciplinary experience that aids students at replicating real life projects. Instructors from all three disciplines guide the students during the course work and supervise the project activities. The fifteen-week course can adopt different types of cybersecurity systems and provide a framework for students’ collaboration on a practical project. The frameworkconsists of four modules divided between the three disciplines: 1) project scope, system integration, and teamwork incorporation; 2) system engineering, cybersecurity design, and application development; 3) system cybersecurity algorithms, data collection, organization, and analytics; 4) system business planning, cybersecurity applications operations implementation, and maintenance. The paper also presents an example for an IoT based project to apply the framework and show the projected course model in developing the IoT project.